ea0049gp141 | Female Reproduction | ECE2017
Shorakae Soulmaz
, Lambert Elisabeth
, Jona Eveline
, Sari Carolina Ika
, de Courten Barbora
, Lambert Gavin
, Teede Helena
The role of the sympathetic nervous system (SNS) in the pathophysiology of PCOS and associated cardiometabolic risks is emerging. Previous studies support increased SNS activity in PCOS, potentially contributing to metabolic features via multiple mechanisms including insulin resistance. Moxonidine is a second-generation imidazoline I1 agonist, acting centrally, inhibiting sympathetic outflow at the level of rostral ventrolateral medulla with known beneficial effects...